Magaldrate
General Information:
Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric
ulcers, esophagitis from gastro esophageal reflux. Magaldrate has a variable composition
corresponding approximately to Al5Mg10 (OH) 31(SO4)2.xH2O and contains Mg (OH) 2 content
Between 49.2 % to 66.6 % on Dried Basis and Between 32.1 % to 45.9 % Al (OH) 3 content on
Dried Basis and Between 16.0 % to 21.0 % SO4 content on Dried Basis and Between 90% to
105% of Al5Mg10 (OH) 31(SO4)2 Assay on Dried Basis.
Molecular Structure:
Nomenclature:
- CAS No.:74978-16-8
- Molecular Formula: Al5Mg10(OH)31(SO4)2, x. H2O
- Molecular Weight: 1097.38 gm/mol
- Synonyms: Aluminium Magnesium Hydroxide Sulfate
Physical Property:
- Physical state: White or almost white, crystalline powder
- Solubility: : Practically insoluble in water and in ethanol (96%). It is soluble in dilute mineral acids
- PH: 8.0 – 10.5 (5 % Aqueous solution)
Application & Use:
Magaldrate is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastro esophageal reflux. Magaldrate is a hydrated complex of hydroxy magnesium aluminate. It initially reacts rapidly with acid and releases aluminium hydroxide which then acts more slowly. The freshly released alum hydroxide is in the impolymerized, more reactive form. It is a good antacid with prompt and sustained
neutralizing action. Simethicone when added offers additional benefit by preventing flatulence development.
Advantage & Disadvantage:
Magaldrate is used to treat a sour stomach, acid indigestion, heartburn and gas. It is an antacid that neutralizes the stomach acid and slowly increases the pH level of the stomach. There are very few possible side effects of Magaldrate that include intestinal pain, constipation and diarrhea. More serious side effects that need medical attention are loss of appetite, tarry stools, slow reflexes, vomiting and rashes.
Shelf Life:
- Expiry: 5 Years after date of manufacture
Storage Recommendations:
Store Protected From Moisture
Packaging:
25 kg net weight packed in LDPE Liner follow by HDPE Woven Bag.
Specifications
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